Dapagliflozin in heart failure: new frontiers

Physical exercise and microRNAs: new frontiers in heart failure.

Although the impact of exercise on survival of patients with heart failure has been recently questioned, exercise training improves quality of life, functional capacity, inflammation, endothelial and autonomic function. In recent years, interest has increased regarding a group of small non-protein coding RNAs called microRNAs. Studies have shown that the expression of these molecules changes in...

Frontiers in congestive heart failure: heart failure in a cold climate. Seasonal variation in heart failure-related morbidity and mortality.

OBJECTIVES This study was done to determine whether seasonal variation exists in hospitalizations and deaths due to heart failure (HF) and to examine possible contributors to such variability. BACKGROUND Although seasonal variation in the incidence of acute myocardial infarction and sudden death is well recognized, it is less well documented in HF. METHODS We used the linked Scottish Morbid...

Frontiers in congestive heart failure: improvement in exercise tolerance and symptoms of congestive heart failure during treatment with candesartan cilexetil.

Background—The renin-angiotensin system plays an important part in the pathogenesis of congestive heart failure (CHF). This study evaluated the effect of an angiotensin II type 1 receptor antagonist on exercise tolerance and symptoms of CHF. Methods and Results—In this multicenter, double-blind, parallel-group study, 844 patients with CHF were randomized to 12 weeks’ treatment with placebo (n52...

NEW FRONTIERS IN ANGIOGENESIS New Frontiers in Angiogenesis

New frontiers in arrhythmias.

Understanding of the mechanisms responsible for disorders of cardiac rhythm has been increasing rapidly in the past I0 years. A great stimulus to these advances in knowledge has been the recognition in Coronary Care Units of the high mortality associated with some arrhythmias. The principal inroads that have been made into the high mortality of patients with acute myocardial infarction who are ...